Ancient haplotypes of the HLA Class II region | Zendy

Christopher K. Raymond | Zendy; Arnold Kas | Zendy; Marcia N. Paddock | Zendy; Ruolan Qiu | Zendy; Yang Zhou | Zendy; Sandhya Subramanian | Zendy; Jean L. Chang | Zendy; Anthony Palmieri | Zendy; Eric Haugen | Zendy; Rajinder Kaul | Zendy; Maynard V. Olson | Zendy

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Ancient haplotypes of the HLA Class II region

Author(s) -

Christopher K. Raymond,

Arnold Kas,

Marcia N. Paddock,

Ruolan Qiu,

Yang Zhou,

Sandhya Subramanian,

Jean L. Chang,

Anthony Palmieri,

Eric Haugen,

Rajinder Kaul,

Maynard V. Olson

Publication year - 2005

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.3554305

Subject(s) - biology , haplotype , genetics , human leukocyte antigen , gene , locus (genetics) , allele , genome , balancing selection , gene conversion , evolutionary biology , antigen

Allelic variation in codons that specify amino acids that line the peptide-binding pockets of HLA's Class II antigen-presenting proteins is superimposed on strikingly few deeply diverged haplotypes. These haplotypes appear to have been evolving almost independently for tens of millions of years. By complete resequencing of 20 haplotypes across the approximately 100-kbp region that spans the HLA-DQA1, -DQB1, and -DRB1 genes, we provide a detailed view of the way in which the genome structure at this locus has been shaped by the interplay of selection, gene-gene interaction, and recombination.

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