Systematic Discovery of New Genes in the Saccharomyces cerevisiae Genome | Zendy

Marco M. Kessler | Zendy; Qiandong Zeng | Zendy; Sarah Hogan | Zendy; Robin Cook | Zendy; Arturo J. Morales | Zendy; Guillaume Cottarel | Zendy

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Systematic Discovery of New Genes in the Saccharomyces cerevisiae Genome

Author(s) -

Marco M. Kessler,

Qiandong Zeng,

Sarah Hogan,

Robin Cook,

Arturo J. Morales,

Guillaume Cottarel

Publication year - 2003

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.232903

Subject(s) - biology , genome , in silico , genetics , gene , comparative genomics , saccharomyces cerevisiae , computational biology , genome project , gene prediction , genomics , proteomics , gene annotation

We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for small open reading frames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.

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