Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain | Zendy

Siling Liu | Zendy; Zhengbo Wang | Zendy; Dong Chen | Zendy; Bowen Zhang | Zendy; RenRong Tian | Zendy; Jing Wu | Zendy; Ying Zhang | Zendy; Kaiyu Xu | Zendy; LiuMeng Yang | Zendy; Chao Cheng | Zendy; Jian Ma | Zendy; Longbao Lv | Zendy; YongTang Zheng | Zendy; Xintian Hu | Zendy; Yi Zhang | Zendy; Xiangting Wang | Zendy; Jiali Li | Zendy

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Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain

Author(s) -

Siling Liu,

Zhengbo Wang,

Dong Chen,

Bowen Zhang,

RenRong Tian,

Jing Wu,

Ying Zhang,

Kaiyu Xu,

LiuMeng Yang,

Chao Cheng,

Jian Ma,

Longbao Lv,

YongTang Zheng,

Xintian Hu,

Yi Zhang,

Xiangting Wang,

Jiali Li

Publication year - 2017

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.217463.116

Subject(s) - biology , macaque , rhesus macaque , epigenetics , gene expression , long non coding rna , messenger rna , genetics , regulation of gene expression , gene , computational biology , rna , neuroscience

Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes and diseases. We applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque ( Macaca mulatta ) brain in four representative age groups. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age, and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression were generally higher than those observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed and functionally validated. Our findings offer a fresh insight into spatial-, age-, and sex-biased changes in lncRNA expression in macaque brain and suggest that the changes represent a previously unappreciated regulatory system that potentially contributes to brain development and aging.

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