Comparative Analysis of the α-Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a Mechanism Underlying Breaks in Conserved Synteny | Zendy

Cristina Tufarelli | Zendy; Ross C. Hardison | Zendy; Webb Miller | Zendy; Jim R. Hughes | Zendy; Kevin Clark | Zendy; Nicki Ventress | Zendy; A.-M. Frischauf | Zendy; Douglas R. Higgs | Zendy

Open Access

Comparative Analysis of the α-Like Globin Clusters in Mouse, Rat, and Human Chromosomes Indicates a Mechanism Underlying Breaks in Conserved Synteny

Author(s) -

Cristina Tufarelli,

Ross C. Hardison,

Webb Miller,

Jim R. Hughes,

Kevin Clark,

Nicki Ventress,

A.-M. Frischauf,

Douglas R. Higgs

Publication year - 2004

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.2143604

Subject(s) - biology , pseudogene , synteny , genetics , chromosome 15 , chromosome 17 (human) , chromosome 16 , chromosome 21 , gene cluster , chromosome 22 , globin , chromosome , gene , chromosome 19 , chromosome regions , microbiology and biotechnology , genome

We have sequenced and fully annotated a 65,871-bp region of mouse Chromosome 17 including the Hba-ps4 alpha-globin pseudogene. Comparative sequence analysis with the functional alpha-globin loci at human Chromosome 16p13.3 and mouse Chromosome 11 shows that this segment of mouse Chromosome 17 contains a group of three alpha-like pseudogenes (Hba-psm-Hba-ps4-Hba-q3), similar to the duplicated sets found at the functional mouse cluster on Chromosome 11. In addition, exons 7 to 12 of the mLuc7L gene are present just downstream from the pseudogene cluster, indicating that this clone contains the region in which human 16p13.3 switches in synteny between mouse Chromosomes 11 and 17. Comparison of the sequences around the alpha-like clusters on the two mouse chromosomes reveals the presence of conserved tandem repeats. We propose that these repetitive elements have played a role in the fragmentation of the mouse alpha cluster during evolution.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research