Genome-Scale Compositional Comparisons in Eukaryotes | Zendy

Andrew J. Gentles | Zendy; Samuel Karlin | Zendy

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Genome-Scale Compositional Comparisons in Eukaryotes

Author(s) -

Andrew J. Gentles,

Samuel Karlin

Publication year - 2001

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.163101

Subject(s) - biology , genome , genetics , drosophila melanogaster , saccharomyces cerevisiae , dna , arabidopsis thaliana , evolutionary biology , gene , mutant

We examined dinucleotide relative abundances and their biases in recent sequences of eukaryotic genomes and chromosomes, including human chromosomes 21 and 22, Saccharomyces cerevisiae, Arabidopsis thaliana, and Drosophila melanogaster. We found that dinucleotide relative abundances are remarkably constant across human chromosomes and within the DNA of a particular species. The dinucleotide biases differ between species, providing a genome signature that is characteristic of the bulk properties of an organism's DNA. We detail the relations between species genome signatures and suggest possible mechanisms for their origin and maintenance.

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