Characterization of the RNA content of chromatin | Zendy

Tanmoy Mondal | Zendy; Markus Rasmussen | Zendy; Gaurav Kumar Pandey | Zendy; Anders Isaksson | Zendy; Chandrasekhar Kanduri | Zendy

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Characterization of the RNA content of chromatin

Author(s) -

Tanmoy Mondal,

Markus Rasmussen,

Gaurav Kumar Pandey,

Anders Isaksson,

Chandrasekhar Kanduri

Publication year - 2010

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.103473.109

Subject(s) - chromatin , biology , intergenic region , non coding rna , chia pet , rna , genetics , gene , transcriptome , regulation of gene expression , gene expression , computational biology , chromatin remodeling , genome , microbiology and biotechnology

Noncoding RNA (ncRNA) constitutes a significant portion of the mammalian transcriptome. Emerging evidence suggests that it regulates gene expression in cis or trans by modulating the chromatin structure. To uncover the functional role of ncRNA in chromatin organization, we deep sequenced chromatin-associated RNAs (CARs) from human fibroblast (HF) cells. This resulted in the identification of 141 intronic regions and 74 intergenic regions harboring CARs. The intronic and intergenic CARs show significant conservation across 44 species of placental mammals. Functional characterization of one of the intergenic CARs, Intergenic10 , revealed that it regulates gene expression of neighboring genes through modulating the chromatin structure in cis . Our data suggest that ncRNA is an integral component of chromatin and that it may regulate various biological functions through fine-tuning of the chromatin architecture.

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