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Our challenge in annotating the 2.91-Mb  Adh  region of the Drosophila melanogaster  genome was to identify genetic and genomic features automatically, completely, and precisely within a 6-week period. To do so, we augmented the  MAGPIE  microbial genome annotation system to handle eukaryotic genomic sequence data. The new configuration required the integration of eukaryotic gene-finding tools and DNA repeat tools into the automatic data collection module. It also required us to define in  MAGPIE new strategies to combine data about eukaryotic exon predictions with functional data to refine the exon predictions. At the heart of the resulting new eukaryotic genome annotation system is a reverse comparison of public protein and complementary DNA sequences against the input genome to identify missing exons and to refine exon boundaries. The software modules that add eukaryotic genome annotation capability to  MAGPIE  are available as  EGRET ( E ukaryotic  G enome  R apid E valuation  T ool).

MAGPIE/EGRET Annotation of the 2.9-Mb Drosophila melanogaster Adh Region

`MAGPIE`/`EGRET` Annotation of the 2.9-Mb Drosophila melanogaster Adh Region