ProPhylER: A curated online resource for protein function and structure based on evolutionary constraint analyses | Zendy

Jonathan Binkley | Zendy; Kalpana Karra | Zendy; Andrew Kirby | Zendy; Midori Hosobuchi | Zendy; Eric A. Stone | Zendy; Arend Sidow | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

ProPhylER: A curated online resource for protein function and structure based on evolutionary constraint analyses

Author(s) -

Jonathan Binkley,

Kalpana Karra,

Andrew Kirby,

Midori Hosobuchi,

Eric A. Stone,

Arend Sidow

Publication year - 2009

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.097121.109

Subject(s) - biology , constraint (computer aided design) , computational biology , pipeline (software) , sequence space , proteome , resource (disambiguation) , interface (matter) , sequence (biology) , function (biology) , protein structure prediction , sequence analysis , protein structure , computer science , bioinformatics , evolutionary biology , genetics , gene , mechanical engineering , computer network , pulmonary surfactant , banach space , gibbs isotherm , biochemistry , mathematics , pure mathematics , engineering , programming language

ProPhylER (Protein Phylogeny and Evolutionary Rates) is a next-generation curated proteome resource that uses comparative sequence analysis to predict constraint and mutation impact for eukaryotic proteins. Its purpose is to inform any research program for which protein function and structure are relevant, by the predictive power of evolutionary constraint analyses. ProPhylER currently has nearly 9000 clusters of related proteins, including more than 200,000 sequences. It serves data via two interfaces. The "ProPhylER Interface" displays predictive analyses in sequence space; the "CrystalPainter" maps evolutionary constraints onto solved protein structures. Here we summarize ProPhylER's data content and analysis pipeline, demonstrate the use of ProPhylER's interfaces, and evaluate ProPhylER's unique regional analysis of evolutionary constraint. The high accuracy of ProPhylER's regional analysis complements the high resolution of its single-site analysis to effectively guide and inform structure-function investigations and predict the impact of polymorphisms.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research