An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs) | Zendy

Vardhman K. Rakyan | Zendy; Thomas A. Down | Zendy; Natalie Thorne | Zendy; Paul Flicek | Zendy; Eugene Kulesha | Zendy; Stefan Gräf | Zendy; Eleni M. Tomazou | Zendy; Liselotte Bäckdahl | Zendy; Nathan Johnson | Zendy; Marlis Herberth | Zendy; Kevin Howe | Zendy; David K. Jackson | Zendy; Marcos Miretti | Zendy; Heike Fiegler | Zendy; John C. Marioni | Zendy; Ewan Birney | Zendy; Tim Hubbard | Zendy; Nigel P. Carter | Zendy; Simon Tavaré | Zendy; Stephan Beck | Zendy

Open Access

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

Author(s) -

Vardhman K. Rakyan,

Thomas A. Down,

Natalie Thorne,

Paul Flicek,

Eugene Kulesha,

Stefan Gräf,

Eleni M. Tomazou,

Liselotte Bäckdahl,

Nathan Johnson,

Marlis Herberth,

Kevin Howe,

David K. Jackson,

Marcos Miretti,

Heike Fiegler,

John C. Marioni,

Ewan Birney,

Tim Hubbard,

Nigel P. Carter,

Simon Tavaré,

Stephan Beck

Publication year - 2008

Publication title -

genome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 9.556

H-Index - 297

eISSN - 1549-5469

pISSN - 1088-9051

DOI - 10.1101/gr.077479.108

Subject(s) - biology , dna methylation , methylated dna immunoprecipitation , epigenomics , epigenetics , genome , cpg site , differentially methylated regions , human genome , genetics , computational biology , ensembl , gene , gene expression , genomics

We report a novel resource (methylation profiles of DNA, or mPod) for human genome-wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts, genome-wide DNA methylation reference profiles of 13 normal somatic tissues, placenta, sperm, and an immortalized cell line, a visualization tool that has been integrated with the Ensembl genome browser and a new algorithm for the analysis of immunoprecipitation-based DNA methylation profiles. We demonstrate the utility of our resource by identifying the first comprehensive genome-wide set of tissue-specific differentially methylated regions (tDMRs) that may play a role in cellular identity and the regulation of tissue-specific genome function. We also discuss the implications of our findings with respect to the regulatory potential of regions with varied CpG density, gene expression, transcription factor motifs, gene ontology, and correlation with other epigenetic marks such as histone modifications.

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