Open AccessConservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.
Author(s) -
Lisa V. Goodrich,
Ronald L. Johnson,
Ljiljana Milenković,
Jill A. McMahon,
Matthew P. Scott
Publication year - 1996
Publication title -
genes and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 7.136
H-Index - 438
eISSN - 1549-5477
pISSN - 0890-9369
DOI - 10.1101/gad.10.3.301
Subject(s) - patched , hedgehog , biology , hedgehog signaling pathway , sonic hedgehog , microbiology and biotechnology , transcription factor , signal transduction , smoothened , ectopic expression , transmembrane protein , genetics , gene , receptor
The signaling protein Hedgehog (Hh) controls cell fate and polarizes tissues in both flies and vertebrates. In flies, Hh exerts its effects by opposing the function of a novel transmembrane protein, Patched, while also locally inducing patched (ptc) transcription. We have identified a mouse homolog of ptc which in many tissues is transcribed near cells making either Sonic or Indian hedgehog. In addition, ectopic Sonic hedgehog expression in the mouse central nervous system induces ptc transcription. As in flies, mouse ptc transcription appears to be indicative of hedgehog signal reception. The results support the existence of a conserved signaling pathway used for pattern formation in insects and mammals.