Quantifying between-Host Transmission in Influenza Virus Infections | Zendy

Katherine Johnson | Zendy; Elodie Ghedin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Quantifying between-Host Transmission in Influenza Virus Infections

Author(s) -

Katherine Johnson,

Elodie Ghedin

Publication year - 2019

Publication title -

cold spring harbor perspectives in medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a038422

Subject(s) - virus , transmission (telecommunications) , transmissibility (structural dynamics) , virology , host (biology) , biology , bottleneck , influenza a virus , pandemic , population , genetic diversity , population bottleneck , genetics , covid-19 , gene , medicine , computer science , disease , allele , environmental health , pathology , embedded system , telecommunications , quantum mechanics , microsatellite , vibration , physics , vibration isolation , infectious disease (medical specialty)

The error-prone replication and life cycle of influenza virus generate a diverse set of genetic variants. Transmission between hosts strictly limits both the number of virus particles and the genetic diversity of virus variants that reach a new host and establish an infection. This sharp reduction in the virus population at transmission--the transmission bottleneck--is significant to the evolution of influenza virus and to its epidemic and pandemic potential. This review describes transmission bottlenecks and their effect on the diversity and evolution of influenza virus. It also reviews the methods for calculating and predicting bottleneck sizes and highlights the host and viral determinants of influenza transmissibility.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research