Organellar Calcium Handling in the Cellular Reticular Network | Zendy

WenAn Wang | Zendy; Luis B. Agellon | Zendy; Marek Michalak | Zendy

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Organellar Calcium Handling in the Cellular Reticular Network

Author(s) -

WenAn Wang,

Luis B. Agellon,

Marek Michalak

Publication year - 2019

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a038265

Subject(s) - biology , endoplasmic reticulum , microbiology and biotechnology , golgi apparatus , endocytic cycle , organelle , calcium signaling , membrane contact site , endomembrane system , second messenger system , cellular compartment , reticular connective tissue , intracellular , cell , membrane protein , biochemistry , endocytosis , membrane , anatomy , integral membrane protein

Ca 2+ is an important intracellular messenger affecting diverse cellular processes. In eukaryotic cells, Ca 2+ is handled by a myriad of Ca 2+ -binding proteins found in organelles that are organized into the cellular reticular network (CRN). The network is comprised of the endoplasmic reticulum, Golgi apparatus, lysosomes, membranous components of the endocytic and exocytic pathways, peroxisomes, and the nuclear envelope. Membrane contact sites between the different components of the CRN enable the rapid movement of Ca 2+ , and communication of Ca 2+ status, within the network. Ca 2+ -handling proteins that reside in the CRN facilitate Ca 2+ sensing, buffering, and cellular signaling to coordinate the many processes that operate within the cell.

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