Epicardium in Heart Development | Zendy

Yingxi Cao | Zendy; Sierra Duca | Zendy; Jingli Cao | Zendy

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Epicardium in Heart Development

Author(s) -

Yingxi Cao,

Sierra Duca,

Jingli Cao

Publication year - 2019

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a037192

Subject(s) - biology , regeneration (biology) , progenitor cell , heart development , microbiology and biotechnology , stem cell biology , embryonic stem cell , population , progenitor , stem cell , cell fate determination , neuroscience , anatomy , embryogenesis , embryo , genetics , transcription factor , reproductive technology , demography , sociology , gene

The epicardium, the outermost tissue layer that envelops all vertebrate hearts, plays a crucial role in cardiac development and regeneration and has been implicated in potential strategies for cardiac repair. The heterogenous cell population that composes the epicardium originates primarily from a transient embryonic cell cluster known as the proepicardial organ (PE). Characterized by its high cellular plasticity, the epicardium contributes to both heart development and regeneration in two critical ways: as a source of progenitor cells and as a critical signaling hub. Despite this knowledge, there are many unanswered questions in the field of epicardial biology, the resolution of which will advance the understanding of cardiac development and repair. We review current knowledge in cross-species epicardial involvement, specifically in relation to lineage specification and differentiation during cardiac development.

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