Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions | Zendy

Taojian Tu | Zendy; Jingyu Chen | Zendy; Lulu Chen | Zendy; Bangyan L. Stiles | Zendy

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Dual-Specific Protein and Lipid Phosphatase PTEN and Its Biological Functions

Author(s) -

Taojian Tu,

Jingyu Chen,

Lulu Chen,

Bangyan L. Stiles

Publication year - 2019

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a036301

Subject(s) - pten , phosphatase , dual (grammatical number) , chemistry , biochemistry , microbiology and biotechnology , biology , phosphorylation , signal transduction , art , pi3k/akt/mtor pathway , literature

Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine-protein phosphatase auxilin. Crystal structure analysis of PTEN has revealed a C2 domain that binds to phospholipids in membranes and a phosphatase domain that displays dual-specific activity toward both tyrosine (Y), serine (S)/threonine (T), as well as lipid substrates in vitro. Characterized primarily as a lipid phosphatase, PTEN plays important roles in multiple cellular processes including cell growth/survival as well as metabolism.

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