PTEN in Regulating Hematopoiesis and Leukemogenesis | Zendy

YiLin Wu | Zendy; Haichuan Zhu | Zendy; Hong Wu | Zendy

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PTEN in Regulating Hematopoiesis and Leukemogenesis

Author(s) -

YiLin Wu,

Haichuan Zhu,

Hong Wu

Publication year - 2019

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a036244

Subject(s) - pten , cancer research , haematopoiesis , medicine , biology , signal transduction , microbiology and biotechnology , stem cell , pi3k/akt/mtor pathway

PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. By counteracting the PI3K/AKT/mTOR pathway, PTEN plays an essential role in regulating hematopoietic stem cells (HSCs) self-renewal, migration, lineage commitment, and differentiation. PTEN also plays important roles in suppressing leukemogenesis, especially T-cell acute lymphoblastic leukemia (T-ALL). Herein, we will review the function of PTEN in regulating hematopoiesis and leukemogenesis and discuss potential therapeutic approaches against leukemia with PTEN mutations.

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