Ca2+ Signaling in Exocrine Cells | Zendy

Malini Ahuja | Zendy; Woo Young Chung | Zendy; Weiyin Lin | Zendy; Beth A. McNally | Zendy; Shmuel Muallem | Zendy

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Ca²⁺ Signaling in Exocrine Cells

Author(s) -

Malini Ahuja,

Woo Young Chung,

Weiyin Lin,

Beth A. McNally,

Shmuel Muallem

Publication year - 2019

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a035279

Subject(s) - biology , exocytosis , signal transduction , secretion , microbiology and biotechnology , calcium signaling , cell signaling , biochemistry

Calcium (Ca 2+ ) and cyclic AMP (cAMP) signaling cross talk and synergize to stimulate the cardinal functions of exocrine cells, regulated exocytosis, and fluid and electrolyte secretion. This physiological process requires the organization of the two signaling pathways into complexes at defined cellular domains and close placement. Such domains are formed by membrane contact sites (MCS). This review discusses the basic properties of Ca 2+ signaling in exocrine cells, the role of MCS in the organization of cell signaling and in cross talk and synergism between the Ca 2+ and cAMP signaling pathways and, finally, the mechanism by which the Ca 2+ and cAMP pathways synergize to stimulate epithelial fluid and electrolyte secretion.

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