The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia | Zendy

Francesca Gianni | Zendy; Laura Belver | Zendy; Adolfo A. Ferrando | Zendy

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The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia

Author(s) -

Francesca Gianni,

Laura Belver,

Adolfo A. Ferrando

Publication year - 2019

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a035246

Subject(s) - lymphoblastic leukemia , malignancy , leukemia , progenitor cell , disease , biology , cancer research , medicine , immunology , stem cell , genetics

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.

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