Hepatitis A Virus Genome Organization and Replication Strategy | Zendy

Kevin L. McKnight | Zendy; Stanley M. Lemon | Zendy

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Hepatitis A Virus Genome Organization and Replication Strategy

Author(s) -

Kevin L. McKnight,

Stanley M. Lemon

Publication year - 2018

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a033480

Subject(s) - biology , picornaviridae , capsid , internal ribosome entry site , virology , genome , rna , virus , escrt , rna virus , open reading frame , genetics , gene , poliovirus , ribosome , endosome , peptide sequence , cell

Hepatitis A virus (HAV) is a positive-strand RNA virus classified in the genus Hepatovirus of the family Picornaviridae It is an ancient virus with a long evolutionary history and multiple features of its capsid structure, genome organization, and replication cycle that distinguish it from other mammalian picornaviruses. HAV proteins are produced by cap-independent translation of a single, long open reading frame under direction of an inefficient, upstream internal ribosome entry site (IRES). Genome replication occurs slowly and is noncytopathic, with transcription likely primed by a uridylated protein primer as in other picornaviruses. Newly produced quasi-enveloped virions (eHAV) are released from cells in a nonlytic fashion in a unique process mediated by interactions of capsid proteins with components of the host cell endosomal sorting complexes required for transport (ESCRT) system.

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