Translational Control in Cancer | Zendy

Nathaniel Robichaud | Zendy; Nahum Sonenberg | Zendy; Davide Ruggero | Zendy; Robert J. Schneider | Zendy

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Translational Control in Cancer

Author(s) -

Nathaniel Robichaud,

Nahum Sonenberg,

Davide Ruggero,

Robert J. Schneider

Publication year - 2018

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a032896

Subject(s) - center (category theory) , biology , cancer , library science , translational research , gerontology , genetics , medicine , computer science , microbiology and biotechnology , chemistry , crystallography

The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of gene expression. This is especially true in the cancer setting, as many oncogenes and transforming events are regulated at this level. Cancer-promoting factors that are translationally regulated include cyclins, antiapoptotic factors, proangiogenic factors, regulators of cell metabolism, prometastatic factors, immune modulators, and proteins involved in DNA repair. This review discusses the diverse means by which cancer cells deregulate and reprogram translation, and the resulting oncogenic impacts, providing insights into the complexity of translational control in cancer and its targeting for cancer therapy.

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