Posttranslational Modifications of RAS Proteins | Zendy

Ian M. Ahearn | Zendy; Mo Zhou | Zendy; Mark R. Philips | Zendy

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Posttranslational Modifications of RAS Proteins

Author(s) -

Ian M. Ahearn,

Mo Zhou,

Mark R. Philips

Publication year - 2018

Publication title -

cold spring harbor perspectives in medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a031484

Subject(s) - carcinogenesis , signal transduction , microbiology and biotechnology , enzyme , drug discovery , computational biology , membrane protein , biology , gene , chemistry , biochemistry , membrane

The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of posttranslational modifications (PTMs) that modify their activity or are required for membrane targeting. The enzymes that catalyze the various PTMs are potential targets for anti-RAS drug discovery. The PTMs of RAS proteins are the focus of this review.

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