New Opportunities for Targeting the Androgen Receptor in Prostate Cancer | Zendy

Margaret M. Centenera | Zendy; Luke A. Selth | Zendy; Esmaeil Ebrahimie | Zendy; Lisa M. Butler | Zendy; Wayne D. Tilley | Zendy

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New Opportunities for Targeting the Androgen Receptor in Prostate Cancer

Author(s) -

Margaret M. Centenera,

Luke A. Selth,

Esmaeil Ebrahimie,

Lisa M. Butler,

Wayne D. Tilley

Publication year - 2018

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a030478

Subject(s) - prostate cancer , medicine , foundation (evidence) , research centre , library science , gerontology , cancer , geography , archaeology , computer science

Recent genomic analyses of metastatic prostate cancer have provided important insight into adaptive changes in androgen receptor (AR) signaling that underpin resistance to androgen deprivation therapies. Novel strategies are required to circumvent these AR-mediated resistance mechanisms and thereby improve prostate cancer survival. In this review, we present a summary of AR structure and function and discuss mechanisms of AR-mediated therapy resistance that represent important areas of focus for the development of new therapies.

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