Prostate Stem Cells and Cancer Stem Cells | Zendy

Jia J. Li | Zendy; Michael M. Shen | Zendy

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Prostate Stem Cells and Cancer Stem Cells

Author(s) -

Jia J. Li,

Michael M. Shen

Publication year - 2018

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a030395

Subject(s) - cancer stem cell , stem cell , progenitor cell , prostate cancer , biology , progenitor , cancer research , cancer , microbiology and biotechnology , genetics

Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as in human tissue. We also discuss studies that have investigated the cell type of origin for prostate cancer. In addition, we provide a critical assessment of methodologies used in stem cell analyses and outline directions for future research.

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