Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment? | Zendy

Federica Sallusto | Zendy; Antonino Cassotta | Zendy; Daniel Hoces | Zendy; Mathilde Foglierini | Zendy; Antonio Lanzavecchia | Zendy

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Do Memory CD4 T Cells Keep Their Cell-Type Programming: Plasticity versus Fate Commitment?

Author(s) -

Federica Sallusto,

Antonino Cassotta,

Daniel Hoces,

Mathilde Foglierini,

Antonio Lanzavecchia

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a029421

Subject(s) - biology , context (archaeology) , effector , diversification (marketing strategy) , microbiology and biotechnology , immune system , cell fate determination , immunology , genetics , transcription factor , gene , paleontology , marketing , business

The wide range of effector and memory T cells is instrumental for immune regulation and tailored mechanisms of protection against pathogens. Here, we will focus on human CD4 T cells and discuss T-cell plasticity and intraclonal diversification in the context of a progressive and selective model of CD4 T-cell differentiation.

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