Regulation of Astrocyte Functions in Multiple Sclerosis | Zendy

Michael A. Wheeler | Zendy; Francisco J. Quintana | Zendy

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Regulation of Astrocyte Functions in Multiple Sclerosis

Author(s) -

Michael A. Wheeler,

Francisco J. Quintana

Publication year - 2018

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a029009

Subject(s) - medical school , center (category theory) , gerontology , medicine , sociology , medical education , crystallography , chemistry

Astrocytes play complex roles in health and disease. Here, we review recent findings on molecular pathways that control astrocyte function in multiple sclerosis (MS) as well as new tools for their investigation. In particular, we describe positive and negative regulators of astrocyte-mediated pathogenesis in MS, such as sphingolipid metabolism and aryl hydrocarbon receptor signaling, respectively. In addition, we also discuss the issue of astrocyte heterogeneity and its relevance for the contribution of astrocytes to MS pathogenesis. Finally, we discuss how new genomic tools could transform the study of astrocyte biology in MS.

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