Integration of Cadherin Adhesion and Cytoskeleton atAdherensJunctions | Zendy

RenéMarc Mège | Zendy; Noboru Ishiyama | Zendy

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Integration of Cadherin Adhesion and Cytoskeleton atAdherensJunctions

Author(s) -

RenéMarc Mège,

Noboru Ishiyama

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a028738

Subject(s) - adherens junction , biology , cadherin , microbiology and biotechnology , mechanotransduction , actin cytoskeleton , actin , cytoskeleton , mechanosensitive channels , myosin , cell adhesion , adhesion , cell adhesion molecule , cell , chemistry , genetics , receptor , organic chemistry , ion channel

The cadherin-catenin adhesion complex is the key component of the intercellular adherens junction (AJ) that contributes both to tissue stability and dynamic cell movements in epithelial and nonepithelial tissues. The cadherin adhesion complex bridges neighboring cells and the actin-myosin cytoskeleton, and thereby contributes to mechanical coupling between cells which drives many morphogenetic events and tissue repair. Mechanotransduction at cadherin adhesions enables cells to sense, signal, and respond to physical changes in their environment. Central to this process is the dynamic link of the complex to actin filaments (F-actin), themselves structurally dynamic and subject to tension generated by myosin II motors. We discuss in this review recent breakthroughs in understanding molecular and cellular aspects of the organization of the core cadherin-catenin complex in adherens junctions, its association to F-actin, its mechanosensitive regulation, and dynamics.

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