Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer | Zendy

Juming Yan | Zendy; Mark J. Smyth | Zendy; Michele W.L. Teng | Zendy

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Interleukin (IL)-12 and IL-23 and Their Conflicting Roles in Cancer

Author(s) -

Juming Yan,

Mark J. Smyth,

Michele W.L. Teng

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a028530

Subject(s) - biology , proinflammatory cytokine , cancer , mechanism (biology) , inflammation , immunology , interleukin 23 , immunity , interleukin , cancer research , immune system , interleukin 17 , bioinformatics , cytokine , genetics , philosophy , epistemology

The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. In this review, we discuss the role IL-12 and IL-23 plays in tumor biology from preclinical and clinical data. In particular, we discuss the mechanism by which IL-23 promotes tumor growth and metastases and how the IL-12/IL-23 axis of inflammation can be targeted for cancer therapy.

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