The Role of Aneuploidy in Cancer Evolution | Zendy

Laurent Sansregret | Zendy; Charles Swanton | Zendy

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The Role of Aneuploidy in Cancer Evolution

Author(s) -

Laurent Sansregret,

Charles Swanton

Publication year - 2016

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a028373

Subject(s) - kingdom , cancer , excellence , lung cancer , genealogy , medicine , biology , history , genetics , law , political science , paleontology

Chromosomal aberrations during cell division represent one of the first recognized features of human cancer cells, and modern detection methods have revealed the pervasiveness of aneuploidy in cancer. The ongoing karyotypic changes brought about by chromosomal instability (CIN) contribute to tumor heterogeneity, drug resistance, and treatment failure. Whole-chromosome and segmental aneuploidies resulting from CIN have been proposed to allow "macroevolutionary" leaps that may contribute to profound phenotypic change. In this review, we will outline evidence indicating that aneuploidy and CIN contribute to cancer evolution.

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