Antimalarial Drug Resistance: A Threat to Malaria Elimination | Zendy

Didier Ménard | Zendy; Arjen M. Dondorp | Zendy

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Antimalarial Drug Resistance: A Threat to Malaria Elimination

Author(s) -

Didier Ménard,

Arjen M. Dondorp

Publication year - 2017

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a025619

Subject(s) - malaria , tropical medicine , epidemiology , drug resistance , medicine , unit (ring theory) , environmental health , traditional medicine , geography , family medicine , biology , pathology , psychology , microbiology and biotechnology , mathematics education

Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with artemisinin resistance. Novel regimens and strategies using existing antimalarial drugs will be needed until novel compounds can be deployed. Elimination of artemisinin resistance will imply elimination of all falciparum malaria from the same areas. In vivax malaria, chloroquine resistance is an increasing problem.

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