Plasmodium Sporozoite Biology | Zendy

Friedrich Frischknecht | Zendy; Kai Matuschewski | Zendy

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Plasmodium Sporozoite Biology

Author(s) -

Friedrich Frischknecht,

Kai Matuschewski

Publication year - 2017

Publication title -

cold spring harbor perspectives in medicine

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a025478

Subject(s) - biology , plasmodium (life cycle) , malaria , transmission (telecommunications) , immune system , population , vector (molecular biology) , anopheles , immunology , virology , parasite hosting , medicine , genetics , recombinant dna , environmental health , world wide web , computer science , gene , electrical engineering , engineering

Plasmodium sporozoite transmission is a critical population bottleneck in parasite life-cycle progression and, hence, a target for prophylactic drugs and vaccines. The recent progress of a candidate antisporozoite subunit vaccine formulation to licensure highlights the importance of sporozoite transmission intervention in the malaria control portfolio. Sporozoites colonize mosquito salivary glands, migrate through the skin, penetrate blood vessels, breach the liver sinusoid, and invade hepatocytes. Understanding the molecular and cellular mechanisms that mediate the remarkable sporozoite journey in the invertebrate vector and the vertebrate host can inform evidence-based next-generation drug development programs and immune intervention strategies.

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