TGF-β Family Signaling in Mesenchymal Differentiation | Zendy

Ingo Grafe | Zendy; Stefanie Alexander | Zendy; Jonathan Peterson | Zendy; Taylor Nicholas Snider | Zendy; Benjamin Lévi | Zendy; Brendan Lee | Zendy; Yuji Mishina | Zendy

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TGF-β Family Signaling in Mesenchymal Differentiation

Author(s) -

Ingo Grafe,

Stefanie Alexander,

Jonathan Peterson,

Taylor Nicholas Snider,

Benjamin Lévi,

Brendan Lee,

Yuji Mishina

Publication year - 2017

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a022202

Subject(s) - biology , mesenchymal stem cell , microbiology and biotechnology , signal transduction , transforming growth factor

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development and also contribute to tissue homeostasis and regeneration, although the requirements for both may be distinct. MSC lineage commitment and progression in differentiation are regulated by members of the transforming growth factor-β (TGF-β) family. This review focuses on the roles of TGF-β family signaling in mesenchymal lineage commitment and differentiation into osteoblasts, chondrocytes, myoblasts, adipocytes, and tenocytes. We summarize the reported findings of cell culture studies, animal models, and interactions with other signaling pathways and highlight how aberrations in TGF-β family signaling can drive human disease by affecting mesenchymal differentiation.

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