Dosage Compensation inDrosophila | Zendy

John C. Lucchesi | Zendy; Mitzi I. Kuroda | Zendy

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Dosage Compensation inDrosophila

Author(s) -

John C. Lucchesi,

Mitzi I. Kuroda

Publication year - 2015

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a019398

Subject(s) - dosage compensation , biology , chromatin , gene , epigenetics , x chromosome , histone , genetics , transcription (linguistics) , drosophila (subgenus) , chromosome , microbiology and biotechnology , linguistics , philosophy

Dosage compensation in Drosophila increases the transcription of genes on the single X chromosome in males to equal that of both X chromosomes in females. Site-specific histone acetylation by the male-specific lethal (MSL) complex is thought to play a fundamental role in the increased transcriptional output of the male X. Nucleation and sequence-independent spreading of the complex to active genes serves as a model for understanding the targeting and function of epigenetic chromatin-modifying complexes. Interestingly, two noncoding RNAs are key for MSL assembly and spreading to active genes along the length of the X chromosome.

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