Long-Range Chromatin Interactions | Zendy

Job Dekker | Zendy; Tom Misteli | Zendy

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Long-Range Chromatin Interactions

Author(s) -

Job Dekker,

Tom Misteli

Publication year - 2015

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a019356

Subject(s) - biology , library science , range (aeronautics) , computer science , engineering , aerospace engineering

To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance

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