Erasers of Histone Acetylation: The Histone Deacetylase Enzymes | Zendy

Ed Seto | Zendy; Minoru Yoshida | Zendy

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Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

Author(s) -

Ed Seto,

Minoru Yoshida

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a018713

Subject(s) - acetylation , histone , biology , histone deacetylase , histone deacetylase 2 , chromatin , histone acetyltransferases , biochemistry , hdac11 , epigenetics , enzyme , histone deacetylase 5 , histone modifying enzymes , lysine , microbiology and biotechnology , histone methyltransferase , dna , amino acid , gene

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc- or NAD(+)-dependent mechanisms to deacetylate acetyl lysine substrates. Although removal of histone acetyl epigenetic modification by HDACs regulates chromatin structure and transcription, deacetylation of nonhistones controls diverse cellular processes. HDAC inhibitors are already known potential anticancer agents and show promise for the treatment of many diseases.

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