Clinical Immunology and Multiplex Biomarkers of Human Tuberculosis | Zendy

Gerhard Walzl | Zendy; Mariëlle C. Haks | Zendy; Simone A. Joosten | Zendy; Léanie Kleynhans | Zendy; Katharina Ronacher | Zendy; Tom H. M. Ottenhoff | Zendy

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Clinical Immunology and Multiplex Biomarkers of Human Tuberculosis

Author(s) -

Gerhard Walzl,

Mariëlle C. Haks,

Simone A. Joosten,

Léanie Kleynhans,

Katharina Ronacher,

Tom H. M. Ottenhoff

Publication year - 2014

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a018515

Subject(s) - tuberculosis , immunology , multiplex , context (archaeology) , medicine , disease , immune system , mycobacterium tuberculosis , computational biology , bioinformatics , biology , pathology , paleontology

The discovery of tuberculosis (TB) biomarkers is an important goal in current TB research, because the availability of such markers would have significant impact on TB prevention and treatment. Correlates of protection would greatly facilitate vaccine development and evaluation, whereas correlates of TB disease risk would facilitate early diagnosis and help installing early or preventive treatment. Currently, no such markers are available. This review describes several strategies that are currently being pursued to identify TB biomarkers and places these in a clinical context. The approaches discussed include both targeted and untargeted hypothesis-free strategies. Among the first are the measurements of specific biomarkers in antigen-stimulated peripheral blood, in serum or plasma, and detailed immune cell phenotyping. Among the latter are proteomic, genomic, and transcriptomic (mRNA, miRNA) approaches. Recent and promising developments are described.

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