A Brief History of Epigenetics | Zendy

Gary Felsenfeld | Zendy

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A Brief History of Epigenetics

Author(s) -

Gary Felsenfeld

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a018200

Subject(s) - biology , epigenetics , organism , zygote , gene , genetics , epigenesis , dna , evolutionary biology , computational biology , model organism , dna methylation , gene expression , embryogenesis

The term "epigenetics" was originally used to denote the poorly understood processes by which a fertilized zygote developed into a mature, complex organism. With the understanding that all cells of an organism carry the same DNA, and with increased knowledge of mechanisms of gene expression, the definition was changed to focus on ways in which heritable traits can be associated not with changes in nucleotide sequence, but with chemical modifications of DNA, or of the structural and regulatory proteins bound to it. Recent discoveries about the role of these mechanisms in early development may make it desirable to return to the original definition of epigenetics.

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