Mechanism and Regulation of Meiotic Recombination Initiation | Zendy

Isabel Lam | Zendy; Scott Keeney | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanism and Regulation of Meiotic Recombination Initiation

Author(s) -

Isabel Lam,

Scott Keeney

Publication year - 2014

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a016634

Subject(s) - biology , homologous recombination , meiosis , recombination , mechanism (biology) , dna , cleavage (geology) , microbiology and biotechnology , genetics , dna repair , gene , paleontology , philosophy , epistemology , fracture (geology)

Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appropriate, findings in different organisms are discussed to highlight evolutionary conservation or divergence.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research