Epigenetic Regulation of Epidermal Differentiation | Zendy

Caroli. Perdigoto | Zendy; Víctor Julián Valdés | Zendy; Evan Bardot | Zendy; Elena Ezhkova | Zendy

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Epigenetic Regulation of Epidermal Differentiation

Author(s) -

Caroli. Perdigoto,

Víctor Julián Valdés,

Evan Bardot,

Elena Ezhkova

Publication year - 2014

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a015263

Subject(s) - epigenetics , chromatin , epigenetic regulation of neurogenesis , epigenome , histone , biology , chromatin remodeling , epigenomics , dna methylation , microbiology and biotechnology , histone modifying enzymes , histone code , epigenetics of physical exercise , transcription factor , cellular differentiation , bivalent chromatin , genetics , dna , gene expression , gene , nucleosome

In a cell, the chromatin state is controlled by the highly regulated interplay of epigenetic mechanisms ranging from DNA methylation and incorporation of different histone variants to posttranslational modification of histones and ATP-dependent chromatin remodeling. These changes alter the structure of the chromatin to either facilitate or restrict the access of transcription machinery to DNA. These epigenetic modifications function to exquisitely orchestrate the expression of different genes, and together constitute the epigenome of a cell. In the skin, different epigenetic regulators form a regulatory network that operates to guarantee skin stem cell maintenance while controlling differentiation to multiple skin structures. In this review, we will discuss recent findings on epigenetic mechanisms of skin control and their relationship to skin pathologies.

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