Cell Therapy in Dermatology | Zendy

Gabriela Petrof | Zendy; Alya AbdulWahab | Zendy; John A. McGrath | Zendy

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Cell Therapy in Dermatology

Author(s) -

Gabriela Petrof,

Alya AbdulWahab,

John A. McGrath

Publication year - 2014

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a015156

Subject(s) - medicine , induced pluripotent stem cell , cell therapy , stem cell , clinical trial , dermatology , skin repair , regeneration (biology) , wound healing , pathology , immunology , biology , embryonic stem cell , microbiology and biotechnology , biochemistry , gene

Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in dermatology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.

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