Neuroblastoma and MYCN | Zendy

Miller Huang | Zendy; William A. Weiss | Zendy

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Neuroblastoma and MYCN

Author(s) -

Miller Huang,

William A. Weiss

Publication year - 2013

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a014415

Subject(s) - neuroblastoma , medicine , neurosurgery , neurology , pediatric neurology , general surgery , pediatrics , surgery , biology , psychiatry , genetics , cell culture

Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from undifferentiated neural crest cells. Amplification of the MYC family member, MYCN, is found in ∼25% of cases and correlates with high-risk disease and poor prognosis. Currently, amplification of MYCN remains the best-characterized genetic marker of risk in neuroblastoma. This article reviews roles for MYCN in neuroblastoma and highlights recent identification of other driver mutations. Strategies to target MYCN at the level of protein stability and transcription are also reviewed.

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