Perspectives on Mucus Properties and Formation--Lessons from the Biochemical World | Zendy

Daniel Ambort | Zendy; Malin Johansson | Zendy; Jenny K. Gustafsson | Zendy; Anna Ermund | Zendy; Gunnar C. Hansson | Zendy

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Perspectives on Mucus Properties and Formation--Lessons from the Biochemical World

Author(s) -

Daniel Ambort,

Malin Johansson,

Jenny K. Gustafsson,

Anna Ermund,

Gunnar C. Hansson

Publication year - 2012

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a014159

Subject(s) - mucin , mucus , cystic fibrosis transmembrane conductance regulator , cystic fibrosis , chemistry , covalent bond , bicarbonate , transmembrane protein , calcium , granule (geology) , biochemistry , biophysics , microbiology and biotechnology , biology , organic chemistry , genetics , ecology , receptor , gene , paleontology

Our model of the MUC2 mucin shows a well-organized netlike gel that is cross-linked by six different covalent and noncovalent bonds. When the MUC2 mucin is packed in the mucin granule it is organized by an amino-terminal concatenated ring platform formed at high calcium and low pH. This packing allows an ordered release and a normal mucin expansion when calcium is removed and pH increased by bicarbonate. This process is defective in the absence of cystic fibrosis transmembrane conductance regulator (CFTR)-dependent bicarbonate transport. The expanded secreted mucin is suggested to be self-organizing by properties inherited in the MUC2 mucin and by proteolytic processes.

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