Pluripotent Stem Cell Models of Human Heart Disease | Zendy

Alessandra Moretti | Zendy; KarlLudwig Laugwitz | Zendy; Tatjana Dorn | Zendy; Daniel Sinnecker | Zendy; Christine L. Mummery | Zendy

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Pluripotent Stem Cell Models of Human Heart Disease

Author(s) -

Alessandra Moretti,

KarlLudwig Laugwitz,

Tatjana Dorn,

Daniel Sinnecker,

Christine L. Mummery

Publication year - 2013

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a014027

Subject(s) - induced pluripotent stem cell , stem cell , disease , human induced pluripotent stem cells , neuroscience , human disease , biology , computational biology , phenotype , regenerative medicine , drug discovery , stem cell biology , genome editing , medicine , bioinformatics , pathology , gene , crispr , microbiology and biotechnology , embryonic stem cell , genetics , reproductive technology , embryogenesis

Understanding the molecular basis of many cardiac diseases has been hampered by the lack of appropriate in vitro cell culture models that accurately reflect the human disease phenotypes. In the past few years, remarkable advances in stem cell biology have made possible this long-standing ambition-the generation of human and even patient-specific cellular models of diseases. Combined with other novel technologies in the fields of human genetics, tissue engineering, and gene-targeted manipulation, disease modeling with pluripotent stem cells has the promise to influence modern cardiovascular medicine on several fronts: molecular understanding of pathological mechanisms, early diagnosis, drug development, and effective treatment.

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