Cardiac Cell Lineages that Form the Heart | Zendy

Sigolène M. Meilhac | Zendy; Fabienne Lescroart | Zendy; Cédric Blanpain | Zendy; Margaret Buckingham | Zendy

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Cardiac Cell Lineages that Form the Heart

Author(s) -

Sigolène M. Meilhac,

Fabienne Lescroart,

Cédric Blanpain,

Margaret Buckingham

Publication year - 2014

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a013888

Subject(s) - lineage (genetic) , cardiac cell , heart development , contractility , cardiac function curve , cell lineage , biology , cell , function (biology) , medicine , computational biology , cellular differentiation , evolutionary biology , heart failure , microbiology and biotechnology , genetics , gene , embryonic stem cell

Myocardial cells ensure the contractility of the heart, which also depends on other mesodermal cell types for its function. Embryological experiments had identified the sources of cardiac precursor cells.With the advent of genetic engineering, novel tools have been used to reconstruct the lineage tree of cardiac cells that contribute to different parts of the heart, map the development of cardiac regions, and characterize their genetic signature. Such knowledge is of fundamental importance for our understanding of cardiogenesis and also for the diagnosis and treatment of heart malformations.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

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