mRNA Localization and Translational Control in Drosophila Oogenesis | Zendy

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mRNA Localization and Translational Control in Drosophila Oogenesis

Author(s) -

Paul Lasko

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a012294

Subject(s) - biology , messenger rna , budding yeast , microbiology and biotechnology , translational regulation , drosophila (subgenus) , p bodies , drosophila embryogenesis , subcellular localization , translation (biology) , genetics , saccharomyces cerevisiae , embryo , computational biology , gene , embryogenesis , cytoplasm

Localization of an mRNA species to a particular subcellular region can complement translational control mechanisms to produce a restricted spatial distribution of the protein it encodes. mRNA localization has been studied most in asymmetric cells such as budding yeast, early embryos, and neurons, but the process is likely to be more widespread. This article reviews the current state of knowledge about the mechanisms of mRNA localization and its functions in early embryonic development, focusing on Drosophila where the relevant knowledge is most advanced. Links between mRNA localization and translational control mechanisms also are examined.

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