Regulation of mRNA Translation by Signaling Pathways | Zendy

Philippe P. Roux | Zendy; Ivan Topisirović | Zendy

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Regulation of mRNA Translation by Signaling Pathways

Author(s) -

Philippe P. Roux,

Ivan Topisirović

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a012252

Subject(s) - biology , translation (biology) , translational regulation , microbiology and biotechnology , pi3k/akt/mtor pathway , signal transduction , protein kinase b , kinase , mapk/erk pathway , protein kinase a , phosphorylation , gene expression , regulation of gene expression , messenger rna , gene , genetics

mRNA translation is the most energy consuming process in the cell. In addition, it plays a pivotal role in the control of gene expression and is therefore tightly regulated. In response to various extracellular stimuli and intracellular cues, signaling pathways induce quantitative and qualitative changes in mRNA translation by modulating the phosphorylation status and thus the activity of components of the translational machinery. In this work we focus on the phosphoinositide 3-kinase (PI3K)/AKT and the mitogen-activated protein kinase (MAPK) pathways, as they are strongly implicated in the regulation of translation in homeostasis, whereas their malfunction has been linked to aberrant translation in human diseases, including cancer.

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