The Neurobiology of Opiate Motivation | Zendy

Ryan TingAKee | Zendy; Derek van der Kooy | Zendy

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The Neurobiology of Opiate Motivation

Author(s) -

Ryan TingAKee,

Derek van der Kooy

Publication year - 2012

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a012096

Subject(s) - ventral tegmental area , dopamine , neuroscience , opiate , addiction , dopamine receptor , psychology , reward system , medicine , receptor , dopaminergic

Opiates are a highly addictive class of drugs that have been reported to possess both dopamine-dependent and dopamine-independent rewarding properties. The search for how, if at all, these distinct mechanisms of motivation are related is of great interest in drug addiction research. Recent electrophysiological, molecular, and behavioral work has greatly improved our understanding of this process. In particular, the signaling properties of GABA(A) receptors located on GABA neurons in the ventral tegmental area (VTA) appear to be crucial to understanding the interplay between dopamine-dependent and dopamine-independent mechanisms of opiate motivation.

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