Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis | Zendy

Tomas Ganz | Zendy; Elizabeta Nemeth | Zendy

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Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis

Author(s) -

Tomas Ganz,

Elizabeta Nemeth

Publication year - 2012

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a011668

Subject(s) - erythropoiesis , ineffective erythropoiesis , iron homeostasis , hepcidin , homeostasis , intracellular , metabolism , physiology , biology , anemia , endocrinology , chemistry , microbiology and biotechnology , medicine

Hemoglobinopathies and other disorders of erythroid cells are often associated with abnormal iron homeostasis. We review the molecular physiology of intracellular and systemic iron regulation, and the interactions between erythropoiesis and iron homeostasis. Finally, we discuss iron disorders that affect erythropoiesis as well as erythroid disorders that cause iron dysregulation.

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