PlGF: A Multitasking Cytokine with Disease-Restricted Activity | Zendy

Mieke Dewerchin | Zendy; Peter Carmeliet | Zendy

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PlGF: A Multitasking Cytokine with Disease-Restricted Activity

Author(s) -

Mieke Dewerchin,

Peter Carmeliet

Publication year - 2012

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a011056

Subject(s) - human multitasking , vascular endothelial growth factor , cytokine , vegf receptors , malignancy , medicine , placental growth factor , cancer research , vascular endothelial growth factor a , inflammation , function (biology) , disease , immunology , bioinformatics , biology , genetics , neuroscience

Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family that also comprises VEGF-A (VEGF), VEGF-B, VEGF-C, and VEGF-D. Unlike VEGF, PlGF is dispensable for development and health but has diverse nonredundant roles in tissue ischemia, malignancy, inflammation, and multiple other diseases. Genetic and pharmacological gain-of-function and loss-of-function studies have identified molecular mechanisms of this multitasking cytokine and characterized the therapeutic potential of delivering or blocking PlGF for various disorders.

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