Modeling Parkinson's Disease in Primates: The MPTP Model | Zendy

Grégory Porras | Zendy; Q. Li | Zendy; Erwan Bézard | Zendy

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Modeling Parkinson's Disease in Primates: The MPTP Model

Author(s) -

Grégory Porras,

Q. Li,

Erwan Bézard

Publication year - 2011

Publication title -

cold spring harbor perspectives in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.853

H-Index - 105

eISSN - 2472-5412

pISSN - 2157-1422

DOI - 10.1101/cshperspect.a009308

Subject(s) - mptp , parkinson's disease , primate , disease , neuroscience , pathological , nonhuman primate , medicine , regimen , psychology , biology , pathology , evolutionary biology

International audienceThe 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate models of Parkinson's disease (PD) reproduce most, although not all, of the clinical and pathological hallmarks of PD. The present contribution presents the possibilities offered by the MPTP monkey models of PD to readers with minimal knowledge of PD, emphasizing the diversity of species, route and regimen of administration, symptoms and pathological features. Readers would eventually find out that there is not a single MPTP monkey model of PD but instead MPTP monkey models of PD, each addressing a specific experimental need

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