Wnt Signaling and Injury Repair | Zendy

Jemima Whyte | Zendy; Andrew A. Smith | Zendy; Jill A. Helms | Zendy

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Wnt Signaling and Injury Repair

Author(s) -

Jemima Whyte,

Andrew A. Smith,

Jill A. Helms

Publication year - 2012

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a008078

Subject(s) - wnt signaling pathway , biology , regeneration (biology) , inflammation , microbiology and biotechnology , wound healing , stem cell , signal transduction , bioinformatics , immunology

Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. In this review we summarize recent data elucidating the roles that the Wnt pathway plays in the injury repair process. These data provide a foundation for potential Wnt-based therapeutic strategies aimed at stimulating tissue regeneration.

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