Heparan Sulfate Proteoglycans | Zendy

Sandrine Sarrazin | Zendy; William C. Lamanna | Zendy; Jeffrey D. Esko | Zendy

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Heparan Sulfate Proteoglycans

Author(s) -

Sandrine Sarrazin,

William C. Lamanna,

Jeffrey D. Esko

Publication year - 2011

Publication title -

cold spring harbor perspectives in biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.011

H-Index - 173

ISSN - 1943-0264

DOI - 10.1101/cshperspect.a004952

Subject(s) - glycobiology , biology , library science , environmental ethics , computational biology , glycan , biochemistry , computer science , philosophy , glycoprotein

Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein-heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.

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